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Don't just its sum but will also the practical Qualities of Hb influence general performance. This can be illustrated by the observation that an elevated Hb-O2 affinity favors O2 loading in the lung and survival within an hypoxic environment (Eaton et al., 1974; Hebbel et al., 1978), While a lessened Hb-O2 affinity favors the discharge of O2 from t